Biomarkers in research

Biomarkers are desperately required for the identification and observation of disease progression in Parkinson’s disease. A trait biomarker indicates susceptibility to a disease, a state biomarker is diagnostic of a disease, and a rate biomarker tracks progression of the disease. A biomarker can be clinical, imaging-based, genetic, or biochemical. Various biologic specimens are potential candidates for identifying biochemical biomarkers; these include cerebrospinal fluid, blood components, urine, and skin. These are mostly because of variation within the macromolecule species detected by totally different antibodies, restricted numbers of patients in some studies, or inadequate control of many vital variables. The event of biomarkers for Parkinson’s disease would have tremendous utility. It may prove to be helpful in early diagnosis and in identifying subgroups of Parkinson.


  • Transcranial ultrasound
  • Proteomics
  • Gene expression profiling
  • Saccadic eye movement
  • REM behavior disorder
  • Radiotracer neuroimaging
  • Dopamine transporter
  • Diffusion tensor imaging (DTI)
  • Body fluid biomarkers

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