Mitochondrial dysfunction


A characteristic of aging, and essentially, of all chronic diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis is mitochondrial dysfunction, which is characterized by a less efficiency in the electron transport chain and reductions in the synthesis of high-energy molecules, such as adenosine-5-triphosphate.Mitochondrial dysfunction acts causally in disease pathogenesis and occurs early in all age-related chronic diseases. Disease-specific proteins interact with mitochondria in an impressive number. Mitochondrial dysfunction is linked to Parkinson’s disease through the evidences provided by the induction of Parkinson by neurotoxins that inhibit mitochondrial complex I.


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