Pathophysiology and Pharmacology
Parkinson’s disease is originated from the gradual loss of cells in the substantia nigra of the brain. This is mainly responsible for the assembly of neurotransmitter. Dopamine is a neurotransmitter which transmits signals between two regions of the brain to coordinate activities like movement of limbs. If there is deficiency in dopamine production results in loss of coordination and end up with the symptoms of Parkinson’s Disease. The disease progresses, various areas of the brain and nervous system degenerate to boot inflicting a lots of movement disorder.