Parkinson’s Disease is a chronic and progressive disease of the nervous system and it became worse over time. It is the second most common neurological disorder. In ordinary Conditions, nerve cells exhibit in cerebrum and delivers a neurotransmitter called dopamine that oversees a development, feelings, and co-appointment yet because of unhealthy individual dopamine creation, hence the individual end up with control the development ordinarily. In Germany, has a lifetime prevalence of between 0.1 and 0.3% of the population

Parkinson’s is one of the well-known age-connected neurodegenerative disorders, in return simply to Alzheimer's disease.  There are approximately seven Million individuals affected with Parkinson’s globally. Several studies and theories are considering the danger factors and the protection measures for the onset of the Parkinson, though the results were imperfect and foreseeable. The neuroepidemiology of PD is very complex with susceptibility genes and several modifiable risk factors that can increase and others that can mitigate risks and outcomes

The identification of PD is difficult in earlier stages, it goes on at the end the result is not obtained. There is no direct treatment for PD and there is no biopsy reports or scan reports that confirm the diagnosis. At present, there is no cure for PD. Medication is given in 3 stages: Initial stage includes the drug called Levodopa, which increase the monoamine neurotransmitter in the brain, the second stage shows less severe PD symptoms and the third stage will help to manage the non-motor symptoms as well as depression. Magnetic Resonance Imaging and Computed Tomogram are used by many physicians to find out other relating Parkinson’s diseases such as encephalitis, Tumours, Hydrocephalus. Dopamine level release and activity of the brain can easily detect using PET and SPECT examining

The introduction about Levodopa and the demonstration that dopamine loss is the key pathological feature of PD have revolutionized the field of PD therapeutics. In most cases of Parkinson’s disease, protein deposits called Lewy Bodies. It is unclear whether Lewy bodies play an important role in killing nerve cells or just part of the cells which are responsible to the Parkinson’s disease. Nearly 15 percent of people with PD have motor symptoms that are not controlled with levodopa. A group of drugs that act directly on dopaminergic reports called dopamine against is used as adjuncts to levodopa in the treatment of PD

Parkinson’s disease is not a life-threatening condition. With time, the illness will bring more problems with speech, movement, and brain functioning. Parkinson’s disease is usually accompanied by additional problems, which may be cured, and they are thinking difficulties, swallowing, depression and emotional changes, sleep difficulties, constipation, blood pressure changes, fatigue, pain, and some complications are Insomnia, Urinary Incontinence, Paraesthesia

Parkinson’s disease is originated from the gradual loss of cells in the substantia nigra of the brain. This is mainly responsible for the assembly of neurotransmitter. Dopamine is a neurotransmitter which transmits signals between two regions of the brain to coordinate activities like the movement of limbs. If there is a deficiency in dopamine production results in loss of coordination and end up with the symptoms of Parkinson’s Disease. The disease progresses, various areas of the brain and nervous system degenerate to boot inflicting a lot of movement disorder

To develop a drug or treatment for Parkinson’s disease observational study is being conducted by a scientist in a laboratory to provide patients with a better life. Clinical trials are performed to slow down the rate of suffering and reduce the symptoms. There is no cure for PD as far, but researchers improved more treatment. Trails help to reduce the risk factors. Trails are the best way to find out whether a new treatment is safe, is a benefit to patients, is more effective, is that improving the quality of life with PD

Free radicles have both beneficial and baleful effect on human body parts. Oxidative stress is known to cause many neurological disorders such as Alzheimer’s, Parkinson’s and Amyotrophic Lateral Sclerosis. With oldness, there is a typical failure of the dopamine-producing neurons. In some of the rare situation’s symptoms are seen in children and terms is referred to as Juvenile Parkinsonism

It is important to develop a PD management plan because it is a chronic disease. The individual should get practiced maintaining the stress levels and depression by daily communicating with close people, friends, colleagues. Patients can improve life by following Instructions given by the counsellor. Managing life with PD includes building a healthcare team with proper Doctors, proper intake of medications, exercises, nutritional drink, and proper sleep

Risk factors for the PD mainly depend on age, hereditary, sex and exposure to toxins. The causes of the diseases are believed to be either genetic or environmental. Symptoms and progression of disease will not be the same among the suffering individuals but people with Parkinson’s are at a higher rate of developing related risks. Parkinson’s disease has a chance of creating mental ailment which can be mild or serious. It includes cognition, mood, behavior which are considered as major impairment when compared to normal populational. The common mood swings seen in the patients are despair, eagerness, indifference Melanoma, Neurogenic, Orthostatic Hypotension, Executive dysfunction, Orthostatic hypertension. Now a day’s Head Injury and Gene variation are in addition to an element of PD